About BROVANA

Patients with moderate to very severe chronic obstructive pulmonary disease (COPD) may benefit from treatment with a nebulized long-acting bronchodilator. BROVANA enables patients to breathe better to obtain the dose of medication. BROVANA is taken only twice daily for the long-term maintenance treatment of bronchoconstriction (tightening of the airways) in patients with COPD, including chronic bronchitis and emphysema.

When patients with moderate to very severe COPD may benefit from nebulized therapy

BROVANA may be the right fit

  • Requires minimal PIFR1,2
  • 12-hr bronchodilation, few daily troughs3
  • Minimal dexterity or hand/breath coordination required
  • Provides additional long-acting control when used with existing anticholinergic therapy4
  • Improved lung function within minutes5,6*Improvement defined as 15% increase in FEV.
  • Improved patient-reported overall COPD symptoms7
  • Proven safety profile, fewer exacerbations5,6,8

BROVANA is not indicated for the treatment of acute episodes of bronchospasm.

The five most common adverse events reported in patients taking BROVANA 15 mcg bid and occurring more frequently than in patients taking placebo were: pain (8% vs 5% for placebo), chest pain (7% vs 6% for placebo), back pain (6% vs 2% for placebo), diarrhea (6% vs 4% for placebo), and sinusitis (5% vs 4% for placebo).

BROVANA is covered under Medicare Part B (prior SABA use no longer required) and most managed care plans.

No guarantee of coverage.


References:

1. Global Initiative for Chronic Obstructive Lung Disease (GOLD). Global Strategy for the Diagnosis, Management, and Prevention of Chronic Obstructive Pulmonary Disease (2010). http://www.goldcopd.org. Accessed March 15, 2011. 2. Dolovich MB, Ahrens RC, Hess DR, et al. Device selection and outcomes of aerosol therapy: evidence-based guidelines. Chest. 2005;127(1):335-371. 3. Baumgartner RA, Hanania NA, Calhoun WJ, Sahn SA, Sciarappa K, Hanrahan JP. Nebulized arformoterol in patients with COPD: a 12-week, multicenter, randomized, double-blind, double-dummy, placebo- and active-controlled trial. Clin Ther. 2007;29(2):261-278. 4. Tashkin DP, Donohue JF, Mahler DA, et al. Effects of arformoterol twice daily, tiotropium once daily, and their combination in patients with COPD. Respir Med. 2009;103(4):516-524. 5. BROVANA [prescribing information]. Marlborough, MA: Sunovion Pharmaceuticals Inc; 2011. 6. Hanrahan JP, Hanania NA, Calhoun WJ, Sahn SA, Sciarappa K, Baumgartner RA. Effect of nebulized arformoterol on airway function in COPD: results from two randomized trials. COPD. 2008;5(1):25-34. 7. Data on file, from a pooled analysis of trials 091-050 and 091-051. Sunovion Pharmaceuticals Inc. 8. Hanrahan JP, Grogan DR, Baumgartner RA, et al. Arrhythmias in patients with chronic obstructive pulmonary disease (COPD): occurrence frequency and the effect of treatment with the inhaled long-acting beta2-agonists arformoterol and salmeterol. Medicine. 2008;87(6):319-328.